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BMJ Open 3 , e003838 (2013)

Gut-Brain Axis Serotonin Effects The peptides serotonergic effects extend to peripheral systems relevant to the gut-brain axis

After 24 h, the tongues of controls exhibited subepithelial focal accumulation of neutrophils, pronounced edema with abundant mastocytes in the striated muscle, and the area of macroscopic epithelial defects revealed a lack of surface epithelium with the defect covered by fibrinous exudate containing granulocytes and mononuclear inflammatory cells

Cureus 16(9):e69453

Management typically includes increasing intake of B12-rich foods, using high-quality B12 supplements, and in some cases receiving B12 injections prescribed by a healthcare provider