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If the mechanistic basis of a renal injury is clearly established, it is easier to assess the risk of chemical injury in man, but such data are at present only available for a few chemicals
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The National Institute on Drug Abuse reports increasing emergency department visits involving MDMA, with many cases involving dangerously high body temperatures, dehydration, or complications from mixing with other substances

10.1158/1078-0432.CCR-13-0190 173
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