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However, such interventions, unlike KD, are associated with an elevated risk of adverse outcomes, including malnutrition [8]

Upon changes in mitochondrial function, retrograde signaling pathways are activated to coordinate mitochondrial protein synthesis during biogenesis but also to communicate eventual mitochondrial malfunctions, triggering compensatory responses in the nucleus (232)

Combining JHU083 and programmed cell death protein 1 (PD-1) inhibitors produces better antitumor effects than PD-1 inhibitors alone (Leone et al., 2019)

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