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doi: 10.1016/S0306-4522(03)00040-X

Binding of insulin to its receptor (INSR) leads to phosphorylation of intracellular substrates, such as insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, and other signaling intermediates

6.2 Concluding remarks and future directions In conclusion, this review has systematically traced SFNs journey from its biosynthetic origins in plants to its multifaceted mechanisms of action in human cancer prevention and therapy, ultimately addressing the translational challenges that currently limit its clinical application

Instead, the bulk of the clinical data that supports glutamine supplementation to date exist in clinical studies where glutamine supplementation was used as an adjunct to chemotherapy or radiation therapy to mitigate toxicities from cancer therapies (Table 1) [73]