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Small molecules have been discovered or screened to bind to the different domains of TDP-43, such as the N-terminal domain, the RNA recognition motifs, or the C-terminal domain (33, 35)

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Moreover, thiol-disulfide exchange can occur between PrSH and Sglutathionylated protein (PrSSG): PrSH + PrSSG PrSSG + PrSH

In 1992, the General Accounting Office (GAO)the historical predecessor to the Government Accountability Officereleased the report Womens Health: FDA Needs to Ensure More Study of Gender Differences in Prescription Drug Testing, ushering a new era of focus on the issue of diversity in clinical trials

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