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Since 24 h treatment of adipocytes with an NNMT inhibitor increased intracellular levels of SAM and NAD + , it is likely that prolonged exposures to NNMT inhibitor during differentiation may have resulted in significantly enhanced intracellular flux of SAM and NAD +

This table makes it clear thatAOD-9604is dose-consistent across contexts (200500 mcg), but cycle length and goals determine how its applied
The clinical scenarios on the next page provide some clarification

Boosts energy and focus for activity and daily tasks

NAMPT expression and sirtuin responsiveness are suppressed during evening hours, reducing NAD+ elevation by 4050% compared to morning dosing
