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Studies with fibroblast cell lines from Mrp1 knockout mice show a similar resistance pattern[31] [33], along with modest sensitization to taxanes and MX
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T2DM is primarily recognized as a chronic inflammatory condition, wherein low-grade systemic inflammation plays a key role in disease pathogenesis

Furthermore, the early symptoms of type 2 diabetes and hypertension are also dysfunctions caused by the reduced biological availability of NO in endothelial cells [60,61]

F., & Fraga, M
