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Single + multiple ascending dose and food effect study of AZD7986 in healthy volunteers, PK, PD and safety study (NCT02303574)

doi: 10.1016/j.pnpbp.2020.109913 98

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This triad of hippocampal impairment, limbic hyperexcitability, and prefrontal disinhibition constitutes a core pathological circuit remodeled in chronic pain and mood disorders, highlighting the interplay between structural plasticity and functional network dyssynchrony

The potential to stunt or treat chronic conditions is why agents that block inflammation are so fascinating to scientists