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Potential therapeutic interventions, such as folinic acid and antioxidant therapy, have been identified as promising strategies to counteract MTX-induced hepatotoxicity (Created by BioRender.com).

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The inhibition of anti-CD3-induced T cell proliferation mediated by z-FA-FMK was abolished by the presence of low molecular weight thiols such as GSH, N-acetylcysteine (NAC) and L-cysteine, whereas D-cysteine which cannot be metabolised to GSH has no effect

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