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Additionally, the glutathione S-transferase alpha 3 gene, GSTA3 , contained a hypermethylated CpG site in TI heifers and has been shown to increase ROS production when knocked down in cell culture [72]

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Berghmans S, Hunt J, Roach A, Goldsmith P

The 510(k) clearance process refers to a premarket submission made to the FDA to demonstrate that a new medical device is substantially equivalent to a legally marketed predicate device [129]