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Feng Y, Jia Y, Su L et al (2013) Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin

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3.3 Consequences of excessive ROS production While low and moderately elevated levels of ROS play a role in cellular signaling and maintaining cellular homeostasis, excessive production is associated with cell damage and cell death

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