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Therefore, where evidence is supported by isolated observational or lower quality interventional data, this is considered low-level evidence

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462,476 Early structural work on Bs MntR revealed that the metal-binding pocket was substantially distinct from that of DtxR, with the two metal binding sites physically closer, sharing two bridging ligands, and including two water molecules, allow for heptacoordination of the Mn II ions (Figure 15C)

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