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Engineering human urate oxidase: towards reactivating it as an important therapeutic enzyme

Disruptions in iron homeostasis in the brain can also be a risk factor or exacerbate neuropsychiatric conditions, including depression, anxiety, and cognitive impairments (Al-Hakeim et al., 2020

AMYOTROPHIC LATERAL SCLEROSIS Amyotrophic lateral sclerosis (ALS) is the most common adult motor neuron disease with an incidence of approximately 2 per 100,000 individuals per year (Hardiman et al., 2017
