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In one study, rats were fed a diet containing lead acetate and subsequently developed signs of toxicity such as oxidative damage to lipids and alterations in blood chemistry parameters
These results suggested that the upregulation of GPX1 promotes, while the deficiency of GPX1 suppresses, the survival of SGNs after peroxynitrite injury
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10.1161/CIRCRESAHA.115.306529 97 LinT.-H.LaiH.-L.KaoY.-Y.SunC.-N.HwangM.-J.ChernY
