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These diverse forms of cell death not only eliminate tumor cells directly but also reshape the tumor microenvironment (TME) by releasing damage-associated molecular patterns (DAMPs), tumor-associated antigens (TAAs), and inflammatory cytokines [209]
Noel, R

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Insulin binding causes autophosphorylation of its receptor, resulting in activation and subsequent tyrosine phosphorylation of insulin receptor substrates and binding of the p85 regulatory subunit of phosphatidyl inositol kinase-3 (PI3K)

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