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Studies suggest that Se can influence genes that are important for cellular differentiation and regeneration [98]
The NF-B signaling pathway is involved in pro-inflammatory molecule regulation (TNF-, IL-1, IL-6), immune responses, cellular proliferation, and apoptosis in both physiological and pathological contexts
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Therefore, before initiation of TRT, it is important to consider the possible presence of risk factors of persistent HH and the time since normoprolactinemia was achieved, usually starting after 3-6 months since then (12)
