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Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways
Several studies indicate that triazole-containing drugs are rapidly metabolized by cytochrome P450 enzymes, and although the metabolism of triazole-based PROTACs has not been extensively studied, it is expected that this may affect their bioavailability and therapeutic efficacy 167,174
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Moreover, NRF2 induces the gene expression of SESN2 and PINK1 to promote macroautophagy and mitophagy in the cell response to oxidative stress, respectively [121, 122]
