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Owing to the pH-responsive characteristics of the MOF, the nanoplatform precisely releases over 80% of Vc-Ca within 25 minutes under acidic tumor microenvironment (pH 6.5), compared with less than 10% under physiological conditions (pH 7.4)

Liposomal LNP mRNA systems are transfection competent in vivo and exhibit enhanced extrahepatic transfection properties It is of obvious interest to characterize the in vivo protein expression and biodistributions following i.v

The high ROS environment lowers the activation threshold of mast cells, causing them to degranulate inappropriately and release a flood of inflammatory cytokines, including histamine, interleukins, and tumor necrosis factor-alpha (TNF-a)