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however, in a six-month, follow-up, open trial with the same participants, increasing the dose as needed, based on symptom response and side effects, up to a maximum of 300 mg of magnesium and 1,200 mg of malic acid twice daily led to reductions in all measures of pain and tenderness

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Goulart BK, de Lima MN, de Farias CB, Reolon GK, Almeida VR, et al