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It is also possible that BSO did not completely block GCLC activity at the dose used, and that even a partial inhibition at Day 2 at a dose near the BSO IC 50 was sufficient to trigger the observed massive lipid ROS and ferroptosis phenotypes, given the supply/demand imbalance at this transition point

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Antioxidase-related genes have evolved during adaptation to different hypoxic environments to facilitate their effective defense against ROS

Changes in mitochondrial shape affect cellular energy metabolism and mitochondrial division is thought to be important for partitioning of damaged mitochondria and removing them from the mitochondrial reticulum

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