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Acknowledgements This work was supported by the MICINN Retos MICIN/AEI/10.13039/501100011033, PID2020-117827RB-I00 and MICIN/AEI/10.13039/501100011033 PID2020-117941RB-I00, PID2023-150260OB-I00 and PID2023-151347OB-I00, all of which were co-financed with Fondos FEDER, EXOHEP2-CM (S2022/BMD-7409), and HORIZON-HLTH-2022-STAYHLTH-02 under agreement No 101095679