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It usually occurs due to decreased dopamine production due to dopaminergic neuronal death in the midbrain's substantia nigra, leading to striatal dopamine deficiency, which is responsible for the motor symptoms of PD [2]

[DOI] [PMC free article] [PubMed] [Google Scholar] [103].Vinceti M, Filippini T, Rothman KJ, Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis

A vitamin B12 deficiency can lead to megaloblastic anemia, a condition characterized by a low number of red blood cells that are larger than normal ( Megaloblastic anemia can cause a variety of symptoms and side effects, including ( shortness of breath headache heart palpitations fatigue poor balance memory loss That said, being low in vitamin B12 doesnt always lead to megaloblastic anemia, and many people may only experience mild symptoms like fatigue ( Furthermore, while a deficiency in vitamin B12 may not cause weight gain, it can decrease energy levels and contribute to fatigue, making it harder to stay active and manage your weight

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