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Clinically defined and diagnosed as having a body mass index (BMI) exceeding 30 kg/m 2 , the condition has rapidly risen in the global human population from 4% in 1975 to an astounding 18% (more than quadruple) in 2016

Th2 cells produce IL-4, IL-10, and IL-13, which inhibit Th1 differentiation and sustain and enhance the humoral immune response (immediate response)

Myofascial trigger points are highly sensitive bundles of fibers in tight bands of muscle

Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus

doi: 10.3389/fnut.2022.1071515 41 MushtaqFAkhtarMFSaleemASharifAAkhtarBAskaryAEet al