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This was the first trial that's shown protection against both intestinal damage and symptoms in a gluten challenge setting, so that was really encouraging, Leffler said

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It is imperative to understand when to discard it

The aims of these trials is to achieve fat-selective weight loss, improved body composition and end-organ protection via a triple mechanism effect in people living with obesity [114]

In addition, mitochondrial dysfunction in oligodendrocytes results in endoplasmic reticulum stress 8,9,10 , causing further downregulation of myelin proteins 11 and reduced myelin lipid synthesis 4
