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The CR process regulates the immune and physiological function, and any disruption in it leads to severe diseases, including cardiovascular, neurodegenerative, cancer, etc

[DOI] [PubMed] [Google Scholar] 58.DSouza A, Kurien BT, Rodgers R, Shenoi J, Kurono S, Matsumoto H, Hensley K, Nath SK, Scofield RH

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Serum levels of thyroid hormones and thyroid-stimulating hormone (TSH)-binding inhibitor immunoglobulin (TBII) in patients with Graves disease at weeks 0 and 12 after commencement of methimazole treatment

This doesnt mean IF never worksit means it needs to be implemented carefully, often with hormone support, and discontinued if its making sleep or energy worse