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In this study, patients had a mean age of 31 years (range 16 46 years of age)
Research has confirmed that the Nle4 and D-Phe7 substitutions in MT-1 produce substantially extended in vitro and in vivo stability relative to native -MSH , documenting resistance to endopeptidase cleavage at the position 7 Phe bond and prevention of methionine oxidation that inactivates native -MSH, resulting in prolonged receptor occupancy and sustained downstream signalling

doi: 10.1186/s12891-019-2908-2

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[DOI] [PubMed] [Google Scholar] 181