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In the nervous system, inhibition of mTOR pathway, including its downstream effectors p70S6K and 4E-BP1, usually promotes neuronal apoptosis 11

A key link between infection and autoreactivity is the existence of pre-existing quiescent auto-reactive T cells, which may be initially activated by their cytokine receptors to IL-2 or IL-15, during an anti-infectious immune response

The antioxidant properties of NAC make it particularly useful in treating dysfunction resulting from TBI by mitigating the damaged mitochondrial production of ROS

The acetaldehyde thus produced is oxidized mainly by mitochondrial ALDH2 (Weiner, 1979

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