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Glutathione Peroxidases as Oncotargets
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In addition to the system Xc - /GPX4 antioxidant axis, recent studies have found that GPX4-independent systems, such as the ferroptosis suppressor protein 1 (FSP1)/coenzyme Q 10 (CoQ 10 ) axis and the dihydroorotate dehydrogenase (DHODH)/CoQ 10 axis [38]
AMD, diabetic retinopathy, uveitis all involve barrier breakdown
