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Therapeutic effects of colchicine in the management of Peyronies disease: a randomized double-blind, placebo-controlled study

We showed that inherent anxiety at baseline and elevated expression of the mineralocorticoid receptors (MR) in the hippocampus predisposes to a stress-induced suppression of expression of metabotropic glutamate receptors-2 (mGlu2, a key inhibitor of spontaneous glutamate release) with development of depressive-like behavior via epigenetic mechanisms of histone acetylation [20]

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A person with CVS needs to work closely with their healthcare team to identify triggers and develop a management plan to improve their quality of life