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When it was found that foods containing NAD+ precursors, particularly vitamin B3, may treat the fatal illness pellagra, which is characterized by diarrhea, dermatitis, dementia, and death, the clinical significance of maintaining NAD+ levels was established in the early 1900s

Specifically, the catalytic activities of pyruvate dehydrogenase and -ketoglutarate dehydrogenase are critically dependent on the production of lipoic acid, a straight-chain fatty-acid containing two sulfhydryl groups

Lets separate the facts from the fear, and clear this up once and for all

Mendes, M

The first CIPs were discovered serendipitously by studying the mechanisms of action of natural product immunosuppressants 5,6 , whereas later efforts made it possible to design bifunctional compounds that simultaneously bind two proteins to enforce their proximity 7