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Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

This means its use is prohibited at all times for athletes subject to WADA regulations

doi: 10.1111/j.1742-4658.2004.04542.x

In response to oxidative stress in rat liver, the mRNA level and enzyme activity of Hao1 are significantly suppressed, thereby effectively preventing excessive H 2 O 2 production in peroxisomes and mitigating further oxidative damage [113]
Dosing for confirmed deficiency: 500 to 1,000 mcg per day orally
