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Many of these placebo-controlled studies have demonstrated that folic acid supplementation improved symptoms in severely depressed patients, elderly depressed and demented patients, and those with major acute depression or schizophrenia, particularly in individuals with RBC folate levels below 453 nmol/L (46)

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The gastrointestinal tract plays a key role in Mn uptake, mediated by metal transporters, and these transporters can also contribute to Mn excretion via the gastrointestinal tract and the hepatobiliary system (Aydemir et al., 2020