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It is known that kidneys are implicated in the removal of sRAGE and circulating AGEs and non-AGE ligands are present in CKD (128)

Moreover, these authors found that phagocytic pathway macrophages are the predominant atherosclerotic plaque macrophages and the most abundant macrophages under a condition characterized by dietary and pharmacological intervention-induced atherosclerosis regression characterized by high expression of phagocytosis- associated genes, suggesting that these interventions accelerated the transition of late P2 stage cells into final P2 stage cells

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npj Biofilms Microbomes 9 , (2023)

doi: 10.1038/ncomms15868