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Studies have demonstrated that the combination of natural products and chemotherapeutic drugs can exert synergistic antitumor effects through multiple mechanisms: in addition to directly inhibiting tumor cell proliferation and inducing apoptosis, it can also overcome multidrug resistance (MDR) and reduce the toxic side effects of chemotherapy

THF can function as a coenzyme in the transfer of one-carbon units, critical in a number of important cellular synthetic reactions, perhaps the most important of which is the synthesis of thymidylate

doi: 10.1183/09031936.00173210 71 GaggarA.ChenJ.ChmielJ

These vitamins are like the spark plugs in your cellular engine, making energy production possible

Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption