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Carnitine supplements can also help patients with CACTD although they do not address all symptoms

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The human heart derives up to 70% of its total energy from the beta-oxidation of fatty acids, making the myocardium exquisitely sensitive to carnitine depletion

AGE can also trigger cellular inflammation and facilitate pyroptosis of endothelial cells via the hypoxia-inducible factors- (HIF-)/RAGE/NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signaling pathway, thereby exacerbating brain injury