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Adam Chambers, from the CPMAs Equine Research Facility, and Lydia Brooks, manager of the CPMA Reference and Research Laboratory, stressed how the horses used in their study received no prior cobalt supplementation, and that high cobalt concentrations can persist for extended periods in the horse due to the long terminal half life

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Some patients require slower titration or may not reach the higher maintenance doses (10-15 mg) where weight loss effects are most pronounced