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Notably, MAPKs can also influence cellular redox status: activated ERK enhances antioxidant gene expression, while JNK further exacerbates ROS production [39]

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However, the effect of C677T polymorphisms of MTHFR on cognitive function was not significant in normal subjects as a longitudinal cognitive study showed that the MTHFR C677T polymorphism was not associated with cognitive performance at baseline or over 12 years 49

241 The bacterium responsible for the formation of a large range of unique PUFA metabolites is the strain Bacillus megaterium ALA2, which has been shown to effectively oxidize LA at the 7-, 12-, 13-, 16-, and/or 17-position, producing numerous unique triols and cyclic PUFA metabolites (Scheme 25)

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