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2 , 10 However, the gastrointestinal adverse effects associated with oral therapy are a substantial disadvantage, notably if this results in a longer time for drug absorption and hence a longer time to reach therapeutic effect

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(15) In a separate animal study by Mieczkowska et al., a comparison of liraglutide to dapagliflozin on bone strength and microarchitecture in insulin-resistant and obese mice found no indication of improved bone strength or microarchitecture by either substance

Our results would argue against these adducts being the main mutagens