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Small-molecule inhibitors of cGAS enzymatic activity (e.g., RU.521, G140, PF-06928215) or STING signaling (e.g., H-151, C-176) have shown promise in preclinical neuroinflammation and neurodegeneration models by suppressing excessive type I interferon and cytokine production [12, 196]

Katarina Kasnik, Departments of Pharmacology and Pathology, Medical Faculty University of Zagreb, Zagreb 10000, Croatia

treated people suffering from severe B12 malabsorption with 2,000 g of cyanocobalamin per day (Kuzminski, 1998)

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