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Description
The lungs extensive capillary network and specialized epithelial cell structure make it a target for both systemic and localized drug delivery, as drugs can readily diffuse upon reaching lung tissues [229]

Their overactivation results in accumulation in inflammatory areas, where they generate ROS, activate proteases of soluble proteins, induce innate and adaptive immune responses, release neutrophil extracellular traps (NETs), mediate gene expression and cell signaling, cellular metabolism, ultimately precipitating local tissue damage (61)

1b) [8]

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& Kessler, V
