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Molecules such as fibroblast growth factor 21 (47), BCL2 interacting protein 3/NIP3-like protein X (48) and acteoside (via the NRF2-mitophagy axis) (49) mitigate ferroptosis by restoring mitochondrial function or removing damaged mitochondria, underscoring the protective role of mitophagy against ferroptosis

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Glutathione peroxidase masterfully regulates this balance, scavenging surplus ROS to prevent cellular chaos