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Molecular mechanisms underlying the long-term impact of dietary fat to increase cardiac pyruvate dehydrogenase kinase: regulation by insulin, cyclic AMP and pyruvate

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Retinoic acid has been shown to synergistically increase the expression and phosphorylation of Smad3 in the presence of TGF- during differentiation of CD4 + T cells toward Treg ( 3 (1,25(OH) 2 D 3 ), has been reported to revert TGF--increased OXPHOS and reactive oxygen species (ROS) in human bronchial epithelial cells ( 2 D 3 has also been shown to antagonize TGF--mediated fibrogenesis

Treatment with this drug has been observed to reduce the production of IL-12, known for its pro-inflammatory properties, and increase the production of IL-10, which contributes to the healing process of the intestinal mucosa [113]