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doi: 10.1002/iub.1603

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This may imply conformational changes which don't allow the fragment to accept the helical regularity since disulfide bridges are stronger than the forces stabilizing alpha helix

A small fraction of M6G and M3G excreted with the bile is de-glucuronidated by enzymes produced by the colonic flora, and the resulting morphine undergoes enterohepatic cycling [53]

Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial