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Studies carried out using epithelial cell lines and animal models showed that gliadin was able to induce apoptosis of intestinal epithelial cells through a direct toxic effect (251), including enterocyte atrophy, villi shortening, decreased epithelial disaccharidase activity, increased expression of HLA molecules, and intraepithelial inflammatory activation

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Hence it is tempting to speculate that microbial factors might contribute to these findings, especially in light of the finding that the short-chain fatty acid butyrate, which is produced by the gut microbiota, inhibits proliferation of enteric glia in vivo (275)

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The proposed mechanism involves accumulated effect over the course rather than peak concentrations

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