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Although most of these early studies found a small but significant reduction in cardiac events, no decrease in total mortality was seen

The particular environment of the lipid bilayer, with a water-poor low dielectric core surrounded by a more polar and better hydrated interfacial region, gives the membrane particular biophysical and physicochemical properties and presents a unique environment for chemical reactions to occur

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Although the lack of translatability between mouse studies and human clinical trials is confounding, it is possible that AZD2820 may act as a full agonist on mMC4R and only a partial agonist on hMC4R