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[109] proved that IN delivery of desmopressin peptide to the brain tissue was more efficient as a nasal powder, showing superior bioavailability than commercial nasal liquid spray and sublingual tablet

Moreover, 3 trials had a high risk of bias regarding blinding of participants, personnel [9,24,31], and 3 trials had low-risk outcome assessors [22,29,34]

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25 Absorption of B12 decreases with age due to reduced gastric acid production, poor digestive health, medications, and other impairments

Exogenous GHRH administration enhances slow-wave sleep and GH release, improving subjective sleep quality (Born et al., Neuroscience Letters )