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Under normal conditions, Nrf2 is sequestered in the cytoplasm by its inhibitor, Keap1 (Kelch-like ECH-associated protein 1), which promotes Nrf2s ubiquitination and degradation

RNA Extraction and cDNA Synthesis Commercial ParsTous kit (Iran) was used for extracting RNA, and all steps were done based on the manufacturer's instructions

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Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A)

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