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On the other hand, CPP-CAND, which integrated the positively charged HIV-TAT sequence, demonstrated senolytic activity (Figure

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Research reveals that senescent cells show upregulation of pro-apoptotic initiators PUMA and BIM while anti-apoptotic guardian BCL-2 is reduced, suggesting these cells are ready to undergo apoptosis but the execution is restrained by the FOXO4-p53 interaction