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3 The neurotoxicity of AOs The appearance of A plaques in the brain, known as senile plaques, is a major hallmark of AD (Walker, 2020)
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however, due to limitations in study design and insufficient data, the lack of relevant clinical trials, and limited exploration of the molecular mechanisms, the current findings are insufficient to generate adequate guidelines for use in clinical practice, and more high-quality studies are needed to further clarify the reproductive toxicity of SSRIs

[DOI] [PubMed] [Google Scholar] 30.Nisar M

Further, thermolability studies showed that MMACHC protein is strongly stabilised by cobalamin binding, whereas mutant protein was much less stabilised and only minimally or not at all with CNCbl (Ref
