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ALDHs are overexpressed in subpopulations of cancer cells with stem-like features, where they are involved in several processes including cellular proliferation, differentiation, detoxification and survival, participating in lipids and amino acid metabolism and retinoic acid synthesis

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In addition, the downregulation of nitrogen metabolism enzymes such as GLUL and GLUD1 by HRS may reduce the accumulation of metabolic byproducts like ammonia, alleviating oxidative and metabolic stress [40]

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Inglehart Laboratory for Comparative Social Research, National Research University Higher School of Economics, St

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Protective role of hypoxia-inducible factor-2 against ischemic damage and oxidative stress in the kidney

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10.1111/liv.13568 100

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